R A Forsch Selected Research

N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)

4/2000	Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.
3/2000	The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine.

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R A Forsch Research Topics

Disease

2	Neoplasms (Cancer) 04/2000 - 03/2000

Drug/Important Bio-Agent (IBA)

2	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 04/2000 - 03/2000